COX1/Cyclooxygenase 1 Rabbit Polyclonal Antibody (0807-3)

UNIPROT #

P23219

PROTEIN NAME

COX1/Cyclooxygenase 1

SYNONYMS

COX 1 antibody;COX 3 antibody;COX-1 antibody;COX1 antibody;Cox3 antibody;Cyclooxygenase 1 antibody;Cyclooxygenase 3, included antibody;Cyclooxygenase-1 antibody;EC 1.14.99.1 antibody;Partial COX1 proteins, included antibody;PCOX1 antibody;PGG/HS antibody;PGH synthase 1 antibody;PGH1_HUMAN antibody;PGHS-1 antibody;PGHS1 antibody;PHS 1 antibody;PHS1 antibody;Prostaglandin G/H synthase 1 antibody;Prostaglandin H2 synthase 1 antibody;Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody;Prostaglandin-endoperoxide synthase 1 antibody;PTGHS antibody;PTGS1 antibody

SEQUENCE SIMILARITIES

Belongs to the prostaglandin G/H synthase family.

SUBCELLULAR LOCATION

Microsome membrane, Endoplasmic reticulum membrane.

FUNCTION

Cytochrome c oxidase subunit I, COX1 (also designated COI, MTCO1 or oxidative phosphorylation (OxPhos) Complex IV, subunit I) is one of three mitochondrial DNA (mtDNA) encoded subunits (MTCO1-3) of respiratory Complex IV. Cytochrome c oxidase is a hetero-oligomeric enzyme composed of 13 subunits localized to the mitochondrial inner membrane and is the terminal enzyme complex of the electron transport chain. Complex IV catalyzes the reduction of molecular oxygen to water. The energy released is used to transport protons across the mitochondrial inner membrane. The resulting electro-chemical gradient is necessary for the synthesis of ATP. Complex IV contains 13 polypeptides; COX1, COX2 and COX3 (MTCO1-3) make up the catalytic core and are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc and VIII are nuclear-encoded.