COX2 Mouse Monoclonal Antibody [A3F7] (EM1902-12)

UNIPROT #

P35354

PROTEIN NAME

COX2

SYNONYMS

COX 2 antibody;COX-2 antibody;COX2 antibody;Cyclooxygenase 2 antibody;Cyclooxygenase 2b antibody;Cyclooxygenase antibody;Cyclooxygenase-2 antibody;Cyclooxygenase2 antibody;EC 1.14.99.1 antibody;fj02a10 antibody;Glucocorticoid-regulated inflammatory cyclooxygenase antibody;Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody;GRIPGHS antibody;hCox 2 antibody;Macrophage activation-associated marker protein P71/73 antibody;OTTHUMP00000033524 antibody;PES-2 antibody;PGG/HS antibody;PGH synthase 2 antibody;PGH2_HUMAN antibody;PGHS 2 antibody;PGHS-2 antibody;PGHS2 antibody;PHS 2 antibody;PHS II antibody;PHS2 antibody;Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody;Prostaglandin endoperoxide synthase 2 antibody;Prostaglandin G/H synthase 2 antibody;Prostaglandin G/H synthase 2 precursor antibody;Prostaglandin G/H synthase and cyclooxygenase antibody;Prostaglandin G/H synthase antibody;Prostaglandin H2 synthase 2 antibody;prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody;Prostaglandin-endoperoxide synthase 2 antibody;PTGS2 antibody;ptgs2a antibody;TIS10 antibody;TIS10 protein antibody;unp1239 antibody;wu:fj02a10 antibody

SEQUENCE SIMILARITIES

Belongs to the prostaglandin G/H synthase family.

POST-TRANSLATIONAL MODIFICATION

S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.; Acetylated at Ser-565 by SPHK1. During neuroinflammation, acetylation by SPHK1 promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.

SUBCELLULAR LOCATION

Microsome membrane, endoplasmic reticulum membrane.

FUNCTION

Cytochrome c oxidase subunit 2, also known as cytochrome c oxidase polypeptide II, is a protein that in humans is encoded by the MT-CO2 gene. Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase. It is also one of the three mitochondrial DNA (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of respiratory complex IV. The MT-CO2 gene is located on the p arm of mitochondrial DNA at position 12 and it spans 683 base pairs.[5] The MT-CO2 gene produces a 25.6 kDa protein composed of 227 amino acids.MT-CO2 is a subunit of the enzyme Cytochrome c oxidase (EC 1.9.3.1) (Complex IV), an oligomeric enzymatic complex of the mitochondrial respiratory chain involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. The enzyme complex consists of 3-4 subunits (prokaryotes) to up to 13 polypeptides (mammals). The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices. The structure of MT-CO2 is known to contain one redox center and a binuclear copper A center (CuA). The CuA is located in a conserved cysteine loop at 196 and 200 amino acid positions and conserved histidine at 204. Several bacterial MT-CO2 have a C-terminal extension that contains a covalently bound haem c.