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HSD3B1 Rabbit Polyclonal Antibody (HA500082)

Price: Regular price $315.00

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Catalog# HA500082

Rabbit Polyclonal to HSD3B1

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

HSD3B1 Rabbit Polyclonal Antibody (HA500082)

Immunogen

Synthetic peptide within human hsd3b1 aa 320-373.

Host

Rabbit

Positive Control

Human placenta tissue lysates, MCF-7, LOVO, human placenta tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071181

APPLICATION DILUTION

  • WB

  • 1:2,000-1:5,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:100-1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

42 kDa

Isotype

IgG

TARGET

UNIPROT #

P14060

PROTEIN NAME

HSD3B1

SYNONYMS

3 beta and steroid delta isomerase 1 antibody;3 beta and steroid hydroxy delta 5 steroid dehydrogenase antibody;3 beta HSD I antibody;3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I antibody;3-beta-HSD I antibody;3-beta-hydroxy-5-ene steroid dehydrogenase antibody;3BETAHSD antibody;3BH antibody;3BHS1_HUMAN antibody;3BHSD antibody;Delta-5-3-ketosteroid isomerase antibody;HGNC:5217 antibody;HSD3B antibody;HSD3B1 antibody;HSDB3 antibody;HSDB3A antibody;Hydroxy delta 5 steroid dehydrogenase 3 beta and steroid delta isomerase 1 antibody;Hydroxy delta 5 steroid dehydrogenase antibody;Progesterone reductase antibody;SDR11E1 antibody;Steroid Delta-isomerase antibody;trophoblast antigen antibody;Trophoblast antigen FDO161G antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum, Membrane, Mitochondrion.

FUNCTION

bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta5-steroid precursors to 3-oxo-Delta4-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Expected to use NAD+ as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity.

CITATIONS

  • Tang, C., Jin, M., Ma, B., Cao, B., Lin, C., Xu, S., Li, J., & Xu, Q.

    RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy

  • Xue Qian,et al

    Hexavalent chromium reduces testosterone levels by impairing lipophagy and disrupting lipid metabolism homeostasis: based on a metabolomic analysis

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