PGC1 alpha+beta Recombinant Rabbit Monoclonal Antibody [JF09-71] (ET1702-96)

UNIPROT #

Q86YN6

PROTEIN NAME

PGC1 alpha+beta

SYNONYMS

LEM6 antibody;Ligand effect modulator 6 antibody;PERC antibody;Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha antibody;Peroxisome proliferative activated receptor, gamma, coactivator 1 antibody;Peroxisome proliferator activated receptor gamma coactivator 1 alpha antibody;peroxisome proliferator-activated receptor gamma coactivator 1 beta antibody;Peroxisome proliferator-activated receptor gamma coactivator 1-alpha antibody;Peroxisome proliferator-activated receptor gamma coactivator 1-beta antibody;peroxisome proliferator-activated receptor gamma, coactivator 1 beta antibody;PGC 1 (alpha) antibody;PGC 1 alpha antibody;PGC 1v antibody;PGC-1(beta) antibody;PGC-1-alpha antibody;PGC-1-beta antibody;PGC-1-related estrogen receptor alpha coactivator antibody;PGC1 antibody;PGC1(alpha) antibody;PGC1A antibody;PGC1v antibody;PPAR gamma coactivator 1 alpha antibody;PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6 antibody;PPAR gamma coactivator 1 antibody;PPAR gamma coactivator variant form antibody;PPAR gamma coactivator-1beta antibody;PPAR-gamma coactivator 1-alpha antibody;PPAR-gamma coactivator 1-beta antibody;PPARGC 1 alpha antibody;PPARGC-1-alpha antibody;PPARGC-1-beta antibody;PPARGC1 antibody;PPARGC1A antibody;Ppargc1b antibody;PRGC1_HUMAN antibody;PRGC2_HUMAN antibody

TISSUE SPECIFICITY

Ubiquitous with higher expression in heart, brain and skeletal muscle.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes. PGC-1α is the master regulator of mitochondrial biogenesis. PGC-1α is also the primary regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogeneis. PGC-1α is a transcriptional coactivator that regulates the genes involved in energy metabolism. Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene. The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity.