Lipin 1 Recombinant Rabbit Monoclonal Antibody [JG37-69] (ET7108-51)

UNIPROT #

Q14693

PROTEIN NAME

Lipin 1

SYNONYMS

EC=3.1.3.4 antibody;KIAA0188 antibody;Lipin-1 antibody;Lpin1 antibody;LPIN1_HUMAN antibody;PAP1 antibody;Phosphatidate phosphatase LPIN1 antibody

SEQUENCE SIMILARITIES

Belongs to the lipin family.

TISSUE SPECIFICITY

Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex (By similarity).; Sumoylated.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm. Endoplasmic reticulum.

FUNCTION

Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).