Apolipoprotein A1 Mouse Monoclonal Antibody (M0809-13)

UNIPROT #

P02647

PROTEIN NAME

Apolipoprotein A1

SYNONYMS

Apo-AI antibody;ApoA I antibody;ApoA-I antibody;APOA1 antibody;APOA1_HUMAN antibody;Apolipoprotein A-I(1-242) antibody;Apolipoprotein A1 antibody;Apolipoprotein AI antibody;Apolipoprotein of high density lipoprotein antibody;ApolipoproteinAI antibody;Brp14 antibody;high density lipoprotein uptake antibody;Ltw1 antibody;Lvtw1 antibody;MGC117399 antibody;Sep1 antibody;Sep2 antibody

SEQUENCE SIMILARITIES

Belongs to the apolipoprotein A1/A4/E family.

TISSUE SPECIFICITY

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.; Palmitoylated.; Phosphorylation sites are present in the extracellular medium.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in plasma encoded by the APOA1 gene. It is also found in chylomicrons.and synthesized in the liver and small intestine. It participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) also known as familial hypoalphalipoproteinemia (FHA). Defects in APOA1 are also a cause of the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1).