eIF4EBP1 Recombinant Rabbit Monoclonal Antibody [JJ09-25] (ET1701-83)

UNIPROT #

Q13541

PROTEIN NAME

eIF4EBP1

SYNONYMS

4E-BP1 antibody;4EBP1 antibody;4EBP1_HUMAN antibody;BP 1 antibody;eIF4E binding protein 1 antibody;eIF4E-binding protein 1 antibody;Eif4ebp1 antibody;Eukaryotic translation initiation factor 4E-binding protein 1 antibody;PHAS-I antibody;PHASI antibody;Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody

SEQUENCE SIMILARITIES

Belongs to the eIF4E-binding protein family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.; Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.

SUBCELLULAR LOCATION

Cytoplasm, cytosol.

FUNCTION

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of cap-dependent mRNA translation.