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PGC1 alpha+beta Recombinant Rabbit Monoclonal Antibody [JF09-71] (ET1702-96)

Price: Regular price $385.00

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Catalog# ET1702-96

Rabbit Monoclonal to PGC1 alpha+beta

Tested for

  • WB

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

PGC1 alpha+beta Recombinant Rabbit Monoclonal Antibody [JF09-71] (ET1702-96)

Immunogen

Synthetic peptide within human pgc1 alpha aa 755-798 /798 and aa 269-323 /798.

Host

Rabbit

Positive Control

Mouse brain tissue lysate, rat brain tissue lysate, SK-Br-3 cell lysate.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JF09-71

RRID

AB_3070355

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 91/113 kDa

Isotype

IgG

TARGET

UNIPROT #

Q86YN6

PROTEIN NAME

PGC1 alpha+beta

SYNONYMS

LEM6 antibody;Ligand effect modulator 6 antibody;PERC antibody;Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha antibody;Peroxisome proliferative activated receptor, gamma, coactivator 1 antibody;Peroxisome proliferator activated receptor gamma coactivator 1 alpha antibody;peroxisome proliferator-activated receptor gamma coactivator 1 beta antibody;Peroxisome proliferator-activated receptor gamma coactivator 1-alpha antibody;Peroxisome proliferator-activated receptor gamma coactivator 1-beta antibody;peroxisome proliferator-activated receptor gamma, coactivator 1 beta antibody;PGC 1 (alpha) antibody;PGC 1 alpha antibody;PGC 1v antibody;PGC-1(beta) antibody;PGC-1-alpha antibody;PGC-1-beta antibody;PGC-1-related estrogen receptor alpha coactivator antibody;PGC1 antibody;PGC1(alpha) antibody;PGC1A antibody;PGC1v antibody;PPAR gamma coactivator 1 alpha antibody;PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6 antibody;PPAR gamma coactivator 1 antibody;PPAR gamma coactivator variant form antibody;PPAR gamma coactivator-1beta antibody;PPAR-gamma coactivator 1-alpha antibody;PPAR-gamma coactivator 1-beta antibody;PPARGC 1 alpha antibody;PPARGC-1-alpha antibody;PPARGC-1-beta antibody;PPARGC1 antibody;PPARGC1A antibody;Ppargc1b antibody;PRGC1_HUMAN antibody;PRGC2_HUMAN antibody

TISSUE SPECIFICITY

Ubiquitous with higher expression in heart, brain and skeletal muscle.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes. PGC-1α is the master regulator of mitochondrial biogenesis. PGC-1α is also the primary regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogeneis. PGC-1α is a transcriptional coactivator that regulates the genes involved in energy metabolism. Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene. The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity.

CITATIONS

  • Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway

  • Jiali Mi,et al

    (−)-Epigallocatechin-3-O-gallate or (−)-epicatechin enhances lipid catabolism and antioxidant defense in common carp (Cyprinus carpio L.) fed a high-fat diet: Mechanistic insights from the AMPK/Sirt1/PGC-1α signaling pathway

  • Liu Xinghui,et al

    Exercise following joint distraction inhibits muscle wasting and delays the progression of post-traumatic osteoarthritis in rabbits by activating PGC-1α in skeletal …

  • Yiwen Tao,et al

    The total alkaloids of Berberidis Cortex alleviate type 2 diabetes mellitus by regulating gut microbiota, inflammation and liver gluconeogenesis

  • TRAP1 suppresses oral squamous cell carcinoma progression by reducing oxidative phosphorylation metabolism of Cancer-associated fibroblasts

  • Acetyl-coenzyme A acetyltransferase 1 promotes brown adipogenesis by activating the AMPK-PGC1α signaling pathway

  • Zhu, W., Fu, L., Xu, C., Peng, K., Liu, Y., Tang, H., Huang, Y., & Yang, X.

    Enoxacin ameliorates polycystic ovary syndrome by promoting the browning of white adipose tissue and restoring gut dysbiosis

  • MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats

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