Gli1 Recombinant Rabbit Monoclonal Antibody [JF09-08] (ET1702-85)

UNIPROT #

P08151

PROTEIN NAME

Gli1

SYNONYMS

Gli 1 antibody;GLI antibody;GLI family zinc finger 1 antibody;GLI Kruppel family member 1 antibody;gli1 antibody;GLI1_HUMAN antibody;Glioma associated oncogene 1 antibody;Glioma associated oncogene homolog 1 (zinc finger protein) antibody;Glioma associated oncogene homolog antibody;Glioma-associated oncogene antibody;Oncogene GLI antibody;Zfp 5 antibody;Zfp5 antibody;Zinc finger protein GLI 1 antibody;Zinc finger protein GLI1 antibody

SEQUENCE SIMILARITIES

Belongs to the GLI C2H2-type zinc-finger protein family.

TISSUE SPECIFICITY

Detected in testis (at protein level). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated in vitro by ULK3.; Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells. The Gli proteins are the effectors of Hedgehog (Hh) signaling and have been shown to be involved in cell fate determination, proliferation and patterning in many cell types and most organs during embryo development. In the developing spinal cord the target genes of Gli proteins, that are themselves transcription factors, are arranged into a complex gene regulatory network that translates the extracellular concentration gradient of Sonic hedgehog into different cell fates along the dorsoventral axis. The Gli transcription factors activate/inhibit transcription by binding to Gli responsive genes and by interacting with the transcription complex. The Gli transcription factors have DNA binding zinc finger domains which bind to consensus sequences on their target genes to initiate or suppress transcription.