MMP-14 Recombinant Rabbit Monoclonal Antibody [SJ18-09] (ET1606-48)

UNIPROT #

P50281

PROTEIN NAME

MMP-14

SYNONYMS

Matrix metallopeptidase 14 (membrane inserted) antibody;Matrix metalloproteinase 14 antibody;Matrix metalloproteinase-14 antibody;Membrane type 1 matrix metalloproteinase antibody;Membrane type 1 metalloprotease antibody;Membrane type matrix metalloproteinase 1 antibody;Membrane-type matrix metalloproteinase 1 antibody;Membrane-type-1 matrix metalloproteinase antibody;MMP 14 antibody;MMP X1 antibody;MMP-14 antibody;MMP-X1 antibody;Mmp14 antibody;MMP14_HUMAN antibody;MMPX1 antibody;MT MMP 1 antibody;MT-MMP 1 antibody;MT1 MMP antibody;MT1-MMP antibody;MT1MMP antibody;MTMMP 1 antibody;MTMMP1 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M10A family.

TISSUE SPECIFICITY

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.

POST-TRANSLATIONAL MODIFICATION

The precursor is cleaved by a furin endopeptidase.; Tyrosine phosphorylated by PKDCC/VLK.

SUBCELLULAR LOCATION

Membrane, Melanosome, Cytoplasm.

FUNCTION

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Membrane-type matrix metalloproteinases, including MT-MMP-1 (also designated MMP-14), MT-MMP-2 (also designated MMP-15), MT-MMP-3 (also designated MMP-16) and MT-MMP-4 (also designated MMP-17) are type I membrane proteins that function to activate other MMPs. MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover.