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Syndecan 1 Recombinant Rabbit Monoclonal Antibody [JM11-21] (ET1703-42)

Price: Regular price $385.00

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Catalog# ET1703-42

Rabbit Monoclonal to Syndecan 1

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Syndecan 1 Recombinant Rabbit Monoclonal Antibody [JM11-21] (ET1703-42)

Immunogen

Recombinant protein within human syndecan 1 aa 13-274 / 310.

Host

Rabbit

Positive Control

HeLa cell lysate, A431 cell lysate, Daudi cell lysate, Raji cell lysate, Ramos cell lysate, A431, Hela, HepG2, human tonsil tissue, human kidney tissue, human lung tissue, mouse colon tissue, mouse prostate tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM11-21

RRID

AB_3070399

APPLICATION DILUTION

  • WB

  • 1:2,000

  • IF-Cell

  • 1:100

  • IF-Tissue

  • 1:50

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 32 kDa

Isotype

IgG

TARGET

UNIPROT #

P18827

PROTEIN NAME

Syndecan 1

SYNONYMS

CD_antigen antibody;CD138 antibody;CD138 antigen antibody;heparan sulfate proteoglycan fibroblast growth factor receptor antibody;SDC antibody;Sdc1 antibody;SDC1_HUMAN antibody;SYND1 antibody;Syndecan 1 antibody;Syndecan antibody;syndecan proteoglycan 1 antibody;Syndecan-1 antibody

SEQUENCE SIMILARITIES

Belongs to the syndecan proteoglycan family.

POST-TRANSLATIONAL MODIFICATION

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

SUBCELLULAR LOCATION

Membrane, Secreted.

FUNCTION

Syndecan-1 (SYND1), also designated CD138, is a type I integral membrane proteoglycan that contains both chondroitin sulfate and heparan sulfate groups. It is expressed in mouse on pre-B cells, immature B cells and plasma cells. Syndecan-1 is also found on the basolateral surfaces of epithelial cells, endothelial cells of sprouting capillaries and embryonic condensing mesenchymal cells. Syndecan-1 functions as an extracellular matrix receptor which binds to collagens, Fibronectin and Thrombospondin. It has been shown to co-localize with Actin-rich filaments and may act to link the cytoskeleton to the extracellular matrix.

CITATIONS

  • Plasma TNFRSF11B as a New Predictive Inflammatory Marker of Sepsis-ARDS with Endothelial Dysfunction

  • Cen, S., Liu, K., Zheng, Y., Shan, J., Jing, C., Gao, J., Pan, H., Bai, Z., & Liu, Z.

    BRAF Mutation as a Potential Therapeutic Target for Checkpoint Inhibitors: A Comprehensive Analysis of Immune Microenvironment in BRAF Mutated Colon Cancer

  • Zhang, D., Zhang, J. T., Pan, Y., Liu, X. F., Xu, J. W., Cui, W. J., Qiao, X. R., & Dong, L.

    Syndecan-1 Shedding by Matrix Metalloproteinase-9 Signaling Regulates Alveolar Epithelial Tight Junction in Lipopolysaccharide-Induced Early Acute Lung Injury

  • Zhang, D., Zhang, J., Zhang, J., Ji, X., Qi, Q., Xu, J., Pan, Y., Liu, X., Sun, F., Zeng, R., & Dong, L.

    Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption

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