NF-κB p65 Rabbit Polyclonal Antibody (HA500402)

UNIPROT #

Q04206

PROTEIN NAME

NF-κB p65

SYNONYMS

Avian reticuloendotheliosis viral (v rel) oncogene homolog A antibody;MGC131774 antibody;NF kappa B p65delta3 antibody;nfkappabp65 antibody;NFkB p65 antibody;NFKB3 antibody;Nuclear factor kappaB antibody;Nuclear Factor NF Kappa B p65 Subunit antibody;Nuclear factor NF-kappa-B p65 subunit antibody;Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 antibody;OTTHUMP00000233473 antibody;OTTHUMP00000233474 antibody;OTTHUMP00000233475 antibody;OTTHUMP00000233476 antibody;OTTHUMP00000233900 antibody;p65 antibody;p65 NF kappaB antibody;p65 NFkB antibody;relA antibody;TF65_HUMAN antibody;Transcription factor NFKB3 antibody;Transcription factor p65 antibody;v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)) antibody;V rel avian reticuloendotheliosis viral oncogene homolog A antibody;v rel reticuloendotheliosis viral oncogene homolog A (avian) antibody;V rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65 antibody;NF-κB p65;NF κB p65;NF-κB p65

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cell.