CD68 Recombinant Rabbit Monoclonal Antibody [SN07-27] (ET1611-53)

UNIPROT #

P34810

PROTEIN NAME

CD68

SYNONYMS

CD 68 antibody;CD68 antibody;CD68 antigen antibody;CD68 molecule antibody;CD68_HUMAN antibody;DKFZp686M18236 antibody;gp11 antibody;Gp110 antibody;LAMP4 antibody;Macrophage antigen CD68 (microsialin) antibody;MACROPHAGE ANTIGEN CD68 antibody;Macrosialin antibody;SCARD1 antibody;Scavenger receptor class D member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the LAMP family.

TISSUE SPECIFICITY

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated.

SUBCELLULAR LOCATION

Cell membrane, Endosome membrane, Lysosome membrane.

FUNCTION

Human CD68 is a transmembrane glycoprotein, heavily glycosylated in its extracellular domain, with a molecular weight of 110 kD. Its primary sequence consists of 354 amino acids with predicted molecular weight of 37.4 kD if it were not glycosylated. The human CD68 protein is encoded by the "CD68" gene which maps to Chromosome 17. Other names or aliases for this gene in humans and other animals include: CD68 Molecule, CD68 Antigen, GP110, Macrosialin, Scavenger Receptor Class D, Member 1, SCARD1, and LAMP4. The mouse equivalent is known as "macrosialin".