CD68 Rabbit Polyclonal Antibody (ER1902-21)

UNIPROT #

P34810

PROTEIN NAME

CD68

SYNONYMS

CD 68 antibody;CD68 antibody;CD68 antigen antibody;CD68 molecule antibody;CD68_HUMAN antibody;DKFZp686M18236 antibody;gp11 antibody;Gp110 antibody;LAMP4 antibody;Macrophage antigen CD68 (microsialin) antibody;MACROPHAGE ANTIGEN CD68 antibody;Macrosialin antibody;SCARD1 antibody;Scavenger receptor class D member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the LAMP family.

TISSUE SPECIFICITY

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated.

SUBCELLULAR LOCATION

Cell membrane, endosome membrane, lysosome membrane.

FUNCTION

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.