CtBP1 Recombinant Rabbit Monoclonal Antibody [JG39-73] (ET7108-96)

UNIPROT #

Q13363

PROTEIN NAME

CtBP1

SYNONYMS

BARS antibody;brefeldin A- ribosylated substrate antibody;C terminal binding protein 1 antibody;C-terminal-binding protein 1 antibody;CTBP antibody;CtBP1 antibody;CTBP1_HUMAN antibody;MGC104684 antibody

SEQUENCE SIMILARITIES

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

TISSUE SPECIFICITY

Expressed in germinal center B-cells.

POST-TRANSLATIONAL MODIFICATION

The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.; ADP-ribosylated; when cells are exposed to brefeldin A.; Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

CtBP1 is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. CtBP1 and the related protein CtBP2 are characterized as C-terminal binding protein of adenovirus E1A, and they preferentially associate with the E1A via a 5-amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T-cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of δEF1, a cellular zinc finger-homeodomain protein, and thereby enhances δEF1 induced transcriptional silencing. In addition, CtBP complexes with CtIP, a protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. CtIP/CtBP binding to BRCA1 inhibits the transactivation of the p21 promoter, and it is critical for regulating p21 transcription in response to DNA damage.