SOCS1 Recombinant Rabbit Monoclonal Antibody [PSH09-68] (HA723133)

UNIPROT #

O15524

PROTEIN NAME

SOCS1

SYNONYMS

CIS1 antibody;CISH 1 antibody;CISH1 antibody;Cytokine inducible SH2 protein 1 antibody;JAB antibody;JAK binding protein antibody;JAK-binding protein antibody;Janus kinase binding protein antibody;SOCS 1 antibody;SOCS-1 antibody;Socs1 antibody;SOCS1_HUMAN antibody;SSI 1 antibody;SSI-1 antibody;SSI1 antibody;STAT induced STAT inhibitor 1 antibody;STAT-induced STAT inhibitor 1 antibody;Suppressor of cytokine signaling 1 antibody;Supressor of cytokine signalling 1 antibody;TEC interacting protein 3 antibody;Tec-interacting protein 3 antibody;TIP 3 antibody;TIP-3 antibody;TIP3 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasmic vesicle.

FUNCTION

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. SOCS1 orthologs have been identified in several mammals for which complete genome data are available. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3, erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival. Several recent viral studies have shown that viral genes, such as Tax gene product (Tax), encoded by HTLV-1, could hijack SOCS1 to inhibit host antiviral pathways, as a strategy to evade host immunity.