ZAP70 Recombinant Rabbit Monoclonal Antibody [PSH11-52] (HA723344)

UNIPROT #

P43403

PROTEIN NAME

Yes-ZAP70

SYNONYMS

70 kDa zeta associated protein antibody;70 kDa zeta-associated protein antibody;EC 2.7.10.2 antibody;FLJ17670 antibody;FLJ17679 antibody;Selective T cell defect antibody;SRK antibody;STD antibody;Syk related tyrosine kinase antibody;Syk-related tyrosine kinase antibody;Truncated ZAP kinase antibody;Tyrosine protein kinase ZAP70 antibody;Tyrosine-protein kinase ZAP-70 antibody;TZK antibody;ZAP 70 antibody;ZAP70 antibody;ZAP70_HUMAN antibody;Zeta chain associated protein kinase 70kD antibody;Zeta chain associated protein kinase 70kDa antibody;Zeta chain associated protein kinase 70kDa isoform 1 antibody;Zeta chain associated protein kinase 70kDa isoform 2 antibody;Zeta chain of T cell receptor associated protein kinase 70 antibody;Zeta chain TCR associated protein kinase 70kD antibody;Zeta chain TCR associated protein kinase 70kDa antibody

SUBCELLULAR LOCATION

Cytoplasm. Cell membrane.

FUNCTION

ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling. ZAP-70 was initially discovered in TCR-stimulated Jurkat cells, an immortal line of human T lymphocytes, in 1991. Its molecular weight is 70 kDa, and it is a member of the protein-tyrosine kinase family and is a close homolog of SYK. SYK and ZAP70 share a common evolutionary origin and split from a common ancestor in the jawed vertebrates. The importance of ZAP-70 in T cell activation was determined when comparing ZAP-70 expression in patients with SCID (severe combined immunodeficiency). ZAP-70 deficient individuals were found to have no functioning T cells in their peripheral blood, suggesting that ZAP-70 is a critical component of T cell activation and development. ZAP-70 expression in B cells is correlated with the development of chronic lymphocytic leukemia (CLL).