IRF1 Recombinant Rabbit Monoclonal Antibody [SR44-08] (ET1602-28)

UNIPROT #

P10914

PROTEIN NAME

IRF1

SYNONYMS

Interferon regulatory factor 1 antibody;Interferon regulatory factor 1 isoform +I9 antibody;Interferon regulatory factor 1 isoform d78 antibody;Interferon regulatory factor 1 isoform delta4 antibody;Interferon regulatory factor 1 isoform delta7 antibody;IRF 1 antibody;IRF-1 antibody;IRF1 antibody;IRF1_HUMAN antibody;MAR antibody;MAR1 antibody

SEQUENCE SIMILARITIES

Belongs to the IRF family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CK2 and this positively regulates its activity.; Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.; Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon- and ∫) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon- and interferon-∫ genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3 p48 (a component of the ISGF-3 complex) and IFN consensus sequence-binding protein (ICSBP).