CD80 Recombinant Rabbit Monoclonal Antibody [JF100-4] (ET1702-95)

UNIPROT #

P33681

PROTEIN NAME

CD80

SYNONYMS

Activation B7-1 antigen antibody;B lymphocyte activation antigen B7 antibody;B7 antibody;B7-1 antibody;B7-1 antigen antibody;B7.1 antibody;BB1 antibody;CD28 antigen ligand 1 antibody;CD28LG antibody;CD28LG1 antibody;CD80 antibody;CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) antibody;CD80 antigen antibody;CD80 molecule antibody;CD80_HUMAN antibody;Costimulatory factor CD80 antibody;costimulatory molecule variant IgV-CD80 antibody;CTLA-4 counter-receptor B7.1 antibody;LAB7 antibody;T-lymphocyte activation antigen CD80 antibody

TISSUE SPECIFICITY

Expressed on activated B-cells, macrophages and dendritic cells.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28 and CTLA-4 (CD152). CD80 can be found on the surface of various immune cells, including B-cells, monocytes, or T-cells, but most typically at antigen-presenting cells (APCs) such as dendritic cells. CD80 has a crucial role in modulatating T-cell immune function as a checkpoint protein at the immunological synapse. CD80 is the ligand for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. Another ligand of CD80 is programmed death-ligand 1 (PD‐L1), expressed on the surface of T-cells, B-cells, DCs, and macrophages. This interaction is inhibiting and causes a reduction in T-cell activation as well as reduction of cytokine production. Its dissociation constant with CD80 is between the CD28 and CTLA-40 (Kd = 1.4 μM).