Carcino Embryonic Antigen CEA Rabbit Polyclonal Antibody (0807-10)

UNIPROT #

P06731

PROTEIN NAME

Carcino Embryonic Antigen CEA

SYNONYMS

Carcinoembryonic antigen antibody;Carcinoembryonic antigen-related cell adhesion molecule 5 antibody;CD66e antibody;CEA antibody;Ceacam5 antibody;CEAM5_HUMAN antibody;DKFZp781M2392 antibody;Meconium antigen 100 antibody;OTTHUMP00000199032 antibody;OTTHUMP00000199033 antibody;OTTHUMP00000199034 antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. CEA family.

TISSUE SPECIFICITY

Expressed in columnar epithelial and goblet cells of the colon (at protein level). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

POST-TRANSLATIONAL MODIFICATION

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

SUBCELLULAR LOCATION

Cell membrane, Membrane.

FUNCTION

The CD66 (carcinoembryonic antigen, CEA, biliary glycoprotein I, BGP-1, CEACAM) immunoglobulin superfamily of genes encode cell adhesion proteins, which are expressed at higher levels in tumorous tissues than in normal tissues. The human CD66 gene family is a diverse set of glycoproteins of epithelial and hematopoietic lineage that comprises 29 genes, which map to chromosome position 19q13.1-q13.2. CD66A, CD66B, CD66C, CD66D, CD66E and CD66F are the best characterized CD66 antigens, and CD66A-D expression upregulates on the surface of granulocytes upon stimulation. Certain CD66 family members mediate homotypic and heterotypic intercellular adhesion events. CD66E, also known as CEA, is a well known tumor marker and a heavily glycosylated GPI-linked cell surface molecule.