FAM3A Mouse Monoclonal Antibody [7-B9] (M1008-10)

UNIPROT #

P98173

PROTEIN NAME

FAM3A

SYNONYMS

2-19 antibody;2.19 antibody;Cytokine-like protein 2-19 antibody;DLD antibody;DXS560S antibody;FAM3A antibody;FAM3A_HUMAN antibody;family with sequence similarity 3, member A antibody;Protein FAM3A antibody;XAP 7 antibody

SEQUENCE SIMILARITIES

Belongs to the FAM3 family.

TISSUE SPECIFICITY

In similar amounts in testis, pancreas, adrenal, placenta, brain, fetal brain, liver, kidney, skeletal muscle and heart.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The FAM3 gene family is a novel cytokine-like gene family, which includes four members designated as FAM3A, FAM3B, FAM3C, and FAM3D. FAM3A is a secreted protein belonging to the FAM3 family of four alpha -helix bundle cytokines. It is expressed in multiple tissues. Mature human FAM3A shares approximately 93% amino acid sequence identity with the mouse and rat protein.FAM3A belongs to a novel cytokine-like gene family, and its physiological role remains largely unknown. FAM3A activated Akt through the p110α catalytic subunit of PI3K in an insulin-independent manner. Blockade of P2 ATP receptors or downstream phospholipase C (PLC) and IP3R and removal of medium calcium all significantly reduced FAM3A-induced increase in cytosolic free Ca2+ levels and attenuated FAM3A-mediated PI3K/Akt activation. Moreover, FAM3A-induced Akt activation was completely abolished by the inhibition of calmodulin (CaM).