HNP-1 Mouse Monoclonal Antibody [2D2] (EM1701-52)

UNIPROT #

P59665

PROTEIN NAME

HNP-1

SYNONYMS

alpha 1 antibody;DEF1 antibody;DEF1_HUMAN antibody;DEFA1 antibody;DEFA1B antibody;DEFA2 antibody;Defensin 1 antibody;Defensin antibody;Defensin, alpha 1 antibody;Defensin, alpha 1, myeloid related sequence antibody;Defensin, alpha 2 antibody;HNP-1 antibody;HNP-2 antibody;HNP1 antibody;HP-1 antibody;HP-2 antibody;HP1 antibody;HP2 antibody;MRS antibody;Myeloid related sequence antibody;Neutrophil defensin 1 antibody;Neutrophil defensin 2 antibody

SEQUENCE SIMILARITIES

Belongs to the alpha-defensin family.

POST-TRANSLATIONAL MODIFICATION

ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.; Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.