MUC4 Recombinant Rabbit Monoclonal Antibody [JM19-36] (ET1705-13)

UNIPROT #

Q99102

PROTEIN NAME

MUC4

SYNONYMS

Ascites sialoglycoprotein 1 antibody;Ascites sialoglycoprotein 2 antibody;Ascites sialoglycoprotein antibody;ASGP antibody;ASGP-1 antibody;ASGP-2 antibody;HSA276359 antibody;MUC 4 antibody;MUC-4 antibody;Muc4 antibody;MUC4_HUMAN antibody;Mucin 4 antibody;Mucin 4 cell surface associated antibody;Mucin 4 tracheobronchial antibody;Mucin-4 beta chain antibody;Pancreatic adenocarcinoma mucin antibody;Testis mucin antibody;Tracheobronchial mucin antibody;Tracheobronchial mucin Fragment antibody

TISSUE SPECIFICITY

Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines.

DEVELOPMENTAL STAGE

Expressed early in the primitive gut before respiratory and digestive epithelial cells have acquired their tissue and cell specificity. Expressed at the basal surface of the epithelium from week 14 to 26 weeks and then predominantly localized in only parietal cells. Immediately before birth, found in the cytoplasm of the mucous columnar epithelial cells. In the embryo expressed in skin, then disappears late in gestation.

POST-TRANSLATIONAL MODIFICATION

Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.; mucrnin-4 alpha chain is highly O-glycosylated.; mucin-4 beta chain is predominantly N-glycosylated.

SUBCELLULAR LOCATION

Secreted, Cell membrane and Membrane.

FUNCTION

Mucin 4 (MUC 4) is a mucin protein that in humans is encoded by the MUC4 gene. Like other mucins, MUC-4 is a high-molecular weight glycoprotein. The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. MUC-4 has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as endometriosis and inflammatory bowel disease. MUC-4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein, and up to 4,650 kDa with glycosylation.