TLR2 Recombinant Rabbit Monoclonal Antibody [JM22-41] (ET1705-92)

UNIPROT #

O60603

PROTEIN NAME

TLR2

SYNONYMS

CD282 antibody;CD282 antigen antibody;TIL 4 antibody;TIL4 antibody;TLR 2 antibody;TLR2 antibody;TLR2_HUMAN antibody;Toll like receptor 2 antibody;Toll like receptor 2 precursor antibody;Toll-like receptor 2 antibody;Toll/interleukin 1 receptor like 4 antibody;Toll/interleukin 1 receptor like protein 4 antibody;Toll/interleukin receptor like protein 4 antibody;Toll/interleukin-1 receptor-like protein 4 antibody

SEQUENCE SIMILARITIES

Belongs to the Toll-like receptor family.

TISSUE SPECIFICITY

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

POST-TRANSLATIONAL MODIFICATION

Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.; Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2 (By similarity).

SUBCELLULAR LOCATION

Membrane, Phagosome membrane, Membrane raft.

FUNCTION

The TLR family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity, and, like other members of TLR family, it induces NFkB signaling upon activation.