IRF7 Recombinant Rabbit Monoclonal Antibody [SC0617] (ET1610-89)

UNIPROT #

Q92985

PROTEIN NAME

IRF7

SYNONYMS

IMD39 antibody;Interferon regulatory factor 7 antibody;Interferon regulatory factor 7H antibody;IRF 7 antibody;IRF 7A antibody;IRF 7H antibody;IRF-7 antibody;IRF7 antibody;IRF7_HUMAN antibody;IRF7A antibody;IRF7B antibody;IRF7C antibody;IRF7H antibody

SEQUENCE SIMILARITIES

Belongs to the IRF family.

TISSUE SPECIFICITY

Expressed predominantly in spleen, thymus and peripheral blood leukocytes.

POST-TRANSLATIONAL MODIFICATION

Acetylation inhibits its DNA-binding ability and activity.; In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1.; TRAF6-mediated ubiquitination is required for IRF7 activation.; Sumoylated by TRIM28, which inhibits its transactivation activity.; (Microbial infection) Cleaved and inactivated by the protease 3C of enterovirus 71 allowing the virus to disrupt the host type I interferon production.; (Microbial infection) Cleaved and inactivated by the protease 3C of human enterovirus 68D (EV68) allowing the virus to disrupt the host type I interferon production.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response. Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models. The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.