Drebrin Rabbit Polyclonal Antibody (ER1902-55)

UNIPROT #

Q16643

PROTEIN NAME

Drebrin

SYNONYMS

D0S117E antibody;DBN 1 antibody;DBN1 antibody;Developmentally regulated brain protein antibody;Developmentally-regulated brain protein antibody;DKFZp434D064 antibody;DREB_HUMAN antibody;Drebrin 1 antibody;Drebrin antibody;Drebrin E antibody;Drebrin E2 antibody;Drebrin1 antibody;DrebrinE antibody

TISSUE SPECIFICITY

Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level). Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level). Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level). Expressed in peripheral blood lymphocytes, including T-cells (at protein level). Expressed in the brain. Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref.2).

SUBCELLULAR LOCATION

Cell junction, Cell projection, Cytoplasm.

FUNCTION

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections . Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS . Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity).