Syntrophin alpha 1 Recombinant Rabbit Monoclonal Antibody [JG35-62] (ET7108-15)

UNIPROT #

Q13424

PROTEIN NAME

Syntrophin alpha 1

SYNONYMS

59 kDa dystrophin-associated protein A1 acidic component 1 antibody;Acidic alpha 1 syntrophin antibody;Alpha 1 syntrophin antibody;Alpha-1-syntrophin antibody;dJ1187J4.5 antibody;Dystrophin associated protein A1 59kDa acidic component antibody;LQT12 antibody;OTTHUMP00000030650 antibody;Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody;SNT1 antibody;Snta1 antibody;SNTA1_HUMAN antibody;Syntrophin 1 antibody;Syntrophin-1 antibody;TACIP1 antibody

SEQUENCE SIMILARITIES

Belongs to the syntrophin family.

TISSUE SPECIFICITY

High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane.

FUNCTION

The syntrophins are PDZ-domain-containing proteins that facilitate the recruitment of signaling proteins such as NOS1 to the dystrophin-associated protein complex. The syntrophin family are structurally related proteins that contain multiple protein interaction motifs. Syntrophins associate directly with dystrophin, the product of the Duchenne muscular dystrophy locus, and its homologs. α-Syntrophin has an important role in synapse formation and in the organization of utrophin, acetylcholine receptor and acetylcholinester-ase at the neuromuscular synapse. Specifically, NOS1 binds to α-Syntrophin at muscle sarcolemma. β2-Syntrophin is a modular adapter. In muscle cells, β2-Syntrophin interacts with members of the dystrophin family, which in-cludes utrophin.