Cathepsin L Recombinant Rabbit Monoclonal Antibody [PSH03-92] (HA722064)

UNIPROT #

P07711

PROTEIN NAME

Cathepsin L

SYNONYMS

Cathepsin L antibody;cathepsin L, 1 b antibody;Cathepsin L1 antibody;Cathepsin L1 light chain antibody;CathepsinL antibody;CATL antibody;CATL1_HUMAN antibody;cb15 antibody;CTSL antibody;CTSL1 antibody;ctsl1b antibody;FLJ31037 antibody;hgg1 antibody;Major excreted protein antibody;MEP antibody;MGC123162 antibody;wu:fb30g09 antibody

SUBCELLULAR LOCATION

Lysosome, Apical cell membrane, Cytoplasmic vesicle, secretory vesicle, chromaffin granule, Secreted, extracellular space.

FUNCTION

Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. The protein is a cysteine cathepsin, a lysosomal cysteine protease that plays a major role in intracellular protein catabolism. Cathepsin L1 is a member of the Peptidase C1 (cathepsin) MEROPS family, which plays an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.