Galectin 3 Rabbit Polyclonal Antibody (ER1803-82)

UNIPROT #

P17931

PROTEIN NAME

Galectin 3

SYNONYMS

35 kDa lectin antibody;Carbohydrate binding protein 35 antibody;Carbohydrate-binding protein 35 antibody;CBP 35 antibody;CBP35 antibody;Gal-3 antibody;GAL3 antibody;Galactose-specific lectin 3 antibody;Galactoside-binding protein antibody;GALBP antibody;Galectin 3 internal gene,included antibody;Galectin-3 antibody;Galectin3 antibody;GALIG antibody;GBP antibody;IgE binding protein antibody;IgE-binding protein antibody;L 31 antibody;L 34 antibody;L-31 antibody;L-34 galactoside-binding lectin antibody;L31 antibody;Laminin-binding protein antibody;Lectin L-29 antibody;Lectin, galactose binding, soluble 3 antibody;LEG3_HUMAN antibody;LGALS2 antibody;LGALS3 antibody;MAC 2 antigen antibody;Mac-2 antibody;Mac-2 antigen antibody;MAC2 antibody;Macrophage galactose-specific lectin antibody;MGC105387 antibody

TISSUE SPECIFICITY

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Secreted.

FUNCTION

Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of β1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn's disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.