Reelin Recombinant Rabbit Monoclonal Antibody [JA63-13] (ET1704-98)

UNIPROT #

P78509

PROTEIN NAME

Reelin

SYNONYMS

LIS2 antibody;PRO1598 antibody;Reeler antibody;Reelin antibody;RELN antibody;RELN_HUMAN antibody;RL antibody

SEQUENCE SIMILARITIES

Belongs to the reelin family.

TISSUE SPECIFICITY

Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver.

DEVELOPMENTAL STAGE

Expressed in fetal and postnatal brain and liver. Expression in postnatal human brain is high in the cerebellum.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Reelin is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite[9] and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like the subventricular and subgranular zones. It is found not only in the brain but also in the liver, thyroid gland, adrenal gland, Fallopian tube, breast and in comparatively lower levels across a range of anatomical regions.