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GLP-1R Rabbit Polyclonal Antibody (HA500204)

Price: Regular price $315.00

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Catalog# HA500204

Rabbit Polyclonal to GLP-1R

Tested for

  • WB

  • IHC-P

  • IF-Cell

Reacts with

  • Human

  • Mouse

  • Rat

Safety datasheet

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

GLP-1R Rabbit Polyclonal Antibody (HA500204)

Immunogen

Recombinant protein within human glp-1r aa 24-175.

Host

Rabbit

Positive Control

Mouse stomach tissue lysates, SH-SY5Y cell lysate, rat stomach tissue lysate, SH-SY5Y, rat pancreas tissue, human pancreas tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071301

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:100-1:500

  • IF-Cell

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

predicted 53 kDa

Isotype

IgG

TARGET

UNIPROT #

P43220

PROTEIN NAME

GLP-1R

SYNONYMS

GLP 1 R antibody;GLP 1 receptor antibody;GLP 1R antibody;GLP antibody;GLP-1 receptor antibody;GLP-1-R antibody;GLP-1R antibody;GLP1R antibody;GLP1R_HUMAN antibody;Glucagon like peptide 1 receptor antibody;Glucagon-like peptide 1 receptor antibody;MGC138331 antibody;OTTHUMP00000016340 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.

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