14-3-3 epsilon Recombinant Rabbit Monoclonal Antibody [JJ08-40] (ET1701-1)

UNIPROT #

P62258

PROTEIN NAME

14-3-3 epsilon

SYNONYMS

14 3 3 E antibody;14 3 3 epsilon antibody;14 3 3E antibody;14-3-3 protein epsilon antibody;14-3-3E antibody;1433E_HUMAN antibody;Epididymis luminal protein 2 antibody;FLJ45465 antibody;FLJ53559 antibody;HEL2 antibody;KCIP 1 antibody;KCIP1 antibody;MDCR antibody;MDS antibody;Mitochondrial import stimulation factor L subunit antibody;Protein kinase C inhibitor protein1 antibody;Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, epsilon antibody;Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, epsilon polypeptide antibody;Tyrosine 3/tryptophan 5 monooxygenase activation protein epsilon polypeptide antibody;YWHAE antibody

SEQUENCE SIMILARITIES

Belongs to the 14-3-3 family.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Melanosome.

FUNCTION

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer, and microdeletions associated with Miller–Dieker syndrome.