14-3-3 gamma Recombinant Rabbit Monoclonal Antibody [SD20-65] (ET1612-9)

UNIPROT #

P61981

PROTEIN NAME

14-3-3 gamma

SYNONYMS

14 3 3 gamma antibody;14 3 3 protein gamma antibody;14 3 3 protein gamma subtype antibody;14 3 3gamma antibody;14-3-3 protein gamma antibody;1433G_HUMAN antibody;3 monooxygenase/tryptophan 5 monooxgenase activation protein gamma polypeptide antibody;KCIP 1 antibody;KCIP-1 antibody;KCIP1 antibody;N-terminally processed antibody;Protein kinase C inhibitor protein 1 antibody;Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein gamma polypeptide antibody;Ywhag antibody

SEQUENCE SIMILARITIES

Belongs to the 14-3-3 family.

TISSUE SPECIFICITY

Highly expressed in brain, skeletal muscle, and heart.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by various PKC isozymes.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins; by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array of pathogenic cellular activities.