14-3-3 sigma Recombinant Rabbit Monoclonal Antibody [SD2070] (ET1612-41)

UNIPROT #

P31947

PROTEIN NAME

14-3-3 sigma

SYNONYMS

14 3 3 protein sigma antibody;14-3-3 protein sigma antibody;1433S_HUMAN antibody;Epithelial cell marker protein 1 antibody;Er antibody;HME 1 antibody;HME1 antibody;MGC143283 antibody;Mkrn3 antibody;Mme1 antibody;OTTHUMP00000004242 antibody;RP23 137L22.11 antibody;SFN antibody;SFN protein antibody;Stratifin antibody;YWHAS antibody

SEQUENCE SIMILARITIES

Belongs to the 14-3-3 family.

TISSUE SPECIFICITY

Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Secreted.

FUNCTION

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.