NRG3 Recombinant Rabbit Monoclonal Antibody [JE49-84] (ET7109-98)

UNIPROT #

P56975

PROTEIN NAME

NRG3

SYNONYMS

HRG3 antibody;Neuregulin 3 antibody;Neuregulin 3 like polypeptide antibody;Neuregulin-3 antibody;Neuregulin3 antibody;NRG-3 antibody;Nrg3 antibody;NRG3_HUMAN antibody;Pro neuregulin 3 antibody;pro NRG3 antibody;Pro-NRG3 antibody

SEQUENCE SIMILARITIES

Belongs to the neuregulin family.

TISSUE SPECIFICITY

Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.

DEVELOPMENTAL STAGE

Isoform 3 is expressed in fetal brain but not in other fetal tissues.

POST-TRANSLATIONAL MODIFICATION

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.; Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.

SUBCELLULAR LOCATION

Membrane. Secreted.

FUNCTION

Neuregulin 3 also known as NRG3 is a neural-enriched member of the neuregulin protein family which in humans is encoded by the NRG3 gene.[5][6] The NRGs are a group of signaling proteins part of the superfamily of epidermal growth factor; EGF like polypeptide growth factor. These groups of proteins possess an 'EGF-like domain' that consists of six cysteine residues and three disulfide bridges predicted by the consensus sequence of the cysteine residues. Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.