Wnt5a Recombinant Rabbit Monoclonal Antibody [JU30-30] (ET1706-33)

UNIPROT #

P41221

PROTEIN NAME

Wnt5a

SYNONYMS

hWNT 5A antibody;hWNT5A antibody;Protein Wnt 5a antibody;Protein Wnt-5a antibody;Protein Wnt5a antibody;Wingless type MMTV integration site family member 5A antibody;Wnt 5a antibody;WNT 5A protein antibody;WNT 5A protein precursor antibody;WNT5A antibody;WNT5A protein precursor antibody;WNT5A_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the Wnt family.

TISSUE SPECIFICITY

Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). Detected in neonate heart and lung.

POST-TRANSLATIONAL MODIFICATION

Glycosylation is necessary for secretion but not for activity.; Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.; Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

The Wnt genes belong to a family of protooncogenes with at least 13 known members that are expressed in species ranging from Drosophila to man. The name Wnt denotes the relationship of this family to the Drosophila segment polarity gene "wingless" and to its vertebrate ortholog, Int1, a mouse protooncogene. Transcription of Wnt family genes appears to be developmentally regulated in a precise temporal and spatial manner. The Wnt genes encode cysteine-rich putative glycoproteins, which have features typical of secreted growth factors. Northern blot analysis detects expression of Wnt-5a in brain, lung, and heart. At least five distinct Wnt-5a transcripts are observed, which are due to transcript variability 5-prime to the initiation methionine. In situ hybridization detects a complex spatial and temporal pattern of Wnt-5a in the mouse, including expression in the developing central nervous system, limbs, facial processes, and the posterior region of the fetus. Human frizzled-5 is the receptor for the Wnt-5a ligand. It is suggested that Wnt-5a augments primitive hematopoietic development in vivo and represents an in vivo regulator of hematopoietic stem cell function in the human.