NUMB Recombinant Rabbit Monoclonal Antibody [JM10-023] (ET1703-02)

UNIPROT #

P49757

PROTEIN NAME

NUMB

SYNONYMS

c14_5527 antibody;C14orf41 antibody;FLJ31314 antibody;h Numb antibody;h-Numb antibody;Numb antibody;Numb homolog (Drosophila) antibody;Numb homolog antibody;Numb protein homolog antibody;NUMB_HUMAN antibody;Protein numb homolog antibody;Protein S171 antibody;S171 antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on Ser-276 and Ser-295 by CaMK1.; Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

SUBCELLULAR LOCATION

Endosome membrane, Cell membrane.

FUNCTION

Protein numb homolog is a protein that in humans is encoded by the NUMB gene. The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. The protein Numb is coded for by the gene, NUMB, whose mechanism appears to be evolutionarily conserved. Numb has been extensively studied in both invertebrates and mammals, though its function is best understood in Drosophila. Numb plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. During neurogenesis, Numb localizes to one side of the mother cell such that it is distributed selectively to one daughter cell. This asymmetric division allows a daughter cell containing Numb to acquire a different fate than the other daughter cell.