CaV2.3 Rabbit Polyclonal Antibody (ER1803-47)

UNIPROT #

Q15878

PROTEIN NAME

CaV2.3

SYNONYMS

alpha-1 polypeptide antibody;BII antibody;Brain calcium channel II antibody;CAC 1E antibody;CAC1E antibody;CAC1E_HUMAN antibody;CACH 6 antibody;CACH6 antibody;CACNA1E antibody;Cacnl1 a6 antibody;CACNL1A6 antibody;Calcium channel antibody;Calcium channel, L type, alpha 1 polypeptide, isoform 6 antibody;calcium channel, R type antibody;Cav 2.3 antibody;Cchra 1 antibody;Cchra1 antibody;isoform 6 antibody;L type antibody;Voltage dependent R type calcium channel subunit alpha 1E antibody;Voltage gated calcium channel subunit alpha Cav2.3 antibody;Voltage-dependent R-type calcium channel subunit alpha-1E antibody;Voltage-gated calcium channel subunit alpha Cav2.3 antibody

SEQUENCE SIMILARITIES

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily.

TISSUE SPECIFICITY

Expressed in neuronal tissues and in kidney.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the channel's properties. This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in humans is encoded by the CACNA1E gene. They are strongly expressed in cortex, hippocampus, striatum, amygdala and interpeduncular nucleus. They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.