TRPA1 Rabbit Polyclonal Antibody (ER1803-91)

UNIPROT #

O75762

PROTEIN NAME

TRPA1

SYNONYMS

ANKTM 1 antibody;ANKTM1 antibody;Ankyrin-like with transmembrane domains protein 1 antibody;Transformation sensitive protein p120 antibody;Transformation-sensitive protein p120 antibody;Transient receptor potential cation channel subfamily A member 1 antibody;TRPA 1 antibody;Trpa1 antibody;TRPA1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the transient receptor (TC 1.A.4) family.

TISSUE SPECIFICITY

Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.

POST-TRANSLATIONAL MODIFICATION

TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain.; Hydroxylation is required for TRPA1 activity inhibition in normoxia. In hypoxia, the decrease in oxygene concentration diminishes the activity of the hydroxylase EGLN1, thus relieving TRPA1 from inhibition and ultimately leading to channel activation.; Oxidation of Cys-633 and Cys-856 in hyperoxia may override the hydroxylase EGLN1-mediated inhibition, causing TRPA1 activation.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Is also activated by menthol (in vitro). Acts also as a ionotropic cannabinoid receptor by being activated by delta9-tetrahydrocannabinol (THC), the psychoactive component of marijuana. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.