BNIP1 Rabbit Polyclonal Antibody (ER1802-66)

UNIPROT #

Q12981

PROTEIN NAME

BNIP1

SYNONYMS

BCL2 adenovirus E1B 19kD interacting protein 1 antibody;BCL2/adenovirus E1B 19 kDa protein-interacting protein 1 antibody;BNIP1 antibody;MGC41600 antibody;Nip1 antibody;OTTHUMP00000161077 antibody;OTTHUMP00000161078 antibody;OTTHUMP00000161079 antibody;OTTHUMP00000223580 antibody;sec20 antibody;SEC20_HUMAN antibody;SEC20L antibody;Transformation-related gene 8 protein antibody;TRG-8 antibody;TRG8 antibody;Vesicle transport protein SEC20 antibody

SEQUENCE SIMILARITIES

Belongs to the SEC20 family.

TISSUE SPECIFICITY

Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated. 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1. Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Mitochondrion membrane.

FUNCTION

The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria.