PICK1 Recombinant Rabbit Monoclonal Antibody [JG30-80] (ET7108-60)

UNIPROT #

Q9NRD5

PROTEIN NAME

PICK1

SYNONYMS

dJ1039K5 antibody;MGC15204 antibody;OTTHUMP00000028509 antibody;PICK 1 antibody;Pick1 antibody;PICK1_HUMAN antibody;PRKCA binding protein antibody;PRKCA-binding protein antibody;PRKCABP antibody;Protein interacting with C kinase 1 antibody;Protein interacting with PRKCA antibody;Protein interacting with PRKCA 1 antibody;Protein kinase C alpha binding protein antibody;Protein kinase C-alpha-binding protein antibody;Protein that interacts with C kinase 1 antibody

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.; Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).

SUBCELLULAR LOCATION

cytoskeleton, perinuclear region, membrane, postsynaptic density, synaptosome.

FUNCTION

Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKCα activation. PKCα, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKCα. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.