PICK1 Rabbit Polyclonal Antibody (ER1902-97)

UNIPROT #

Q9NRD5

PROTEIN NAME

PICK1

SYNONYMS

dJ1039K5 antibody;MGC15204 antibody;OTTHUMP00000028509 antibody;PICK 1 antibody;Pick1 antibody;PICK1_HUMAN antibody;PRKCA binding protein antibody;PRKCA-binding protein antibody;PRKCABP antibody;Protein interacting with C kinase 1 antibody;Protein interacting with PRKCA antibody;Protein interacting with PRKCA 1 antibody;Protein kinase C alpha binding protein antibody;Protein kinase C-alpha-binding protein antibody;Protein that interacts with C kinase 1 antibody

SUBCELLULAR LOCATION

Cytoskeleton, perinuclear region, membrane, postsynaptic density, synaptosome.

FUNCTION

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.