CHRNA1 Rabbit Polyclonal Antibody (ER1902-58)

UNIPROT #

P02708

PROTEIN NAME

CHRNA1

SYNONYMS

Acetylcholine receptor subunit alpha antibody;ACHA_HUMAN antibody;AChR antibody;ACHRA antibody;ACHRD antibody;CHNRA antibody;Cholinergic receptor nicotinic alpha 1 subunit antibody;Cholinergic receptor nicotinic alpha polypeptide 1 antibody;Cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) antibody;Chrna1 antibody;CMS1A antibody;CMS1B antibody;CMS2A antibody;FCCMS antibody;Nicotinic cholinergic receptor alpha 1 antibody;SCCMS antibody;Schizophrenia neurophysiologic defect candidate antibody

SEQUENCE SIMILARITIES

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.

TISSUE SPECIFICITY

Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.

SUBCELLULAR LOCATION

Postsynaptic cell membrane, cell membrane.

FUNCTION

Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR). The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.