CHRNA3 Rabbit Polyclonal Antibody (ER1902-13)

UNIPROT #

P32297

PROTEIN NAME

CHRNA3

SYNONYMS

ACHA3_HUMAN antibody;AChR antibody;Cholinergic receptor neuronal nicotinic alpha polypeptide 3 antibody;Cholinergic receptor nicotinic alpha 3 antibody;Cholinergic receptor nicotinic alpha polypeptide 3 antibody;CHRNA 3 antibody;CHRNA3 antibody;LNCR2 antibody;MGC104879 antibody;NACHRA 3 antibody;NACHRA3 antibody;Neuronal acetylcholine receptor protein alpha 3 chain precursor antibody;Neuronal acetylcholine receptor subunit alpha 3 antibody;Neuronal acetylcholine receptor subunit alpha-3 antibody;Neuronal nicotinic acetylcholine receptor alpha 3 subunit antibody;PAOD2 antibody

SEQUENCE SIMILARITIES

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.

SUBCELLULAR LOCATION

Plasma membrane.

FUNCTION

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.