DARPP32 Recombinant Rabbit Monoclonal Antibody [SU0329] (ET1608-23)

UNIPROT #

Q9UD71

PROTEIN NAME

DARPP32

SYNONYMS

DARPP 32 antibody;DARPP-32 antibody;Dopamine and cAMP regulated neuronal phosphoprotein 32 antibody;Dopamine and cAMP regulated neuronal phosphoprotein antibody;Dopamine and cAMP regulated phosphoprotein antibody;Dopamine and cAMP regulated phosphoprotein DARPP 32 antibody;Dopamine and cAMP regulated phosphoprotein DARPP32 antibody;Dopamine- and cAMP-regulated neuronal phosphoprotein antibody;FLJ20940 antibody;IPPD antibody;Neuronal phosphoprotein DARPP 32 antibody;PPP1R1B antibody;PPR1B_HUMAN antibody;Protein phosphatase 1 regulatory (inhibitor) subunit 1B antibody;Protein phosphatase 1 regulatory inhibitor subunit 1B antibody;Protein phosphatase 1 regulatory subunit 1B antibody

SEQUENCE SIMILARITIES

Belongs to the protein phosphatase inhibitor 1 family.

POST-TRANSLATIONAL MODIFICATION

Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.; Phosphorylation of Thr-34 is required for activity.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene. Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons that also express dopamine D1 receptors. DARPP-32 is critical for dopamine dependent striatal synaptic plasticity, possibly by serving as a dopamine-dependent gating mechanism for calcium/CaMKII signaling.