KV1.1 Rabbit Polyclonal Antibody (ER1901-23)

UNIPROT #

Q09470

PROTEIN NAME

KV1.1

SYNONYMS

AEMK antibody;EA1 antibody;Episodic ataxia with myokymia antibody;HBK1 antibody;HUK1 antibody;Kca1 1 antibody;Kcna1 antibody;KCNA1_HUMAN antibody;Kcpvd antibody;KV1.1 antibody;MBK1 antibody;mceph antibody;MGC124402 antibody;MGC126782 antibody;MGC138385 antibody;MK1 antibody;MK1, mouse, homolog of KV1.1 antibody;Potassium channel protein 1 antibody;Potassium voltage gated channel shaker related subfamily member 1 antibody;Potassium voltage gated channel subfamily A member 1 antibody;Potassium voltage gated channel, shaker related subfamily, member 1 (episodic ataxia with myokymia) antibody;Potassium voltage-gated channel subfamily A member 1 antibody;RBK1 antibody;RCK1 antibody;Shak antibody;Shaker related subfamily member 1 antibody;Voltage gated potassium channel subunit Kv1.1 antibody;Voltage-gated K(+) channel HuKI antibody;Voltage-gated potassium channel HBK1 antibody;Voltage-gated potassium channel subunit Kv1.1 antibody

SEQUENCE SIMILARITIES

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.

TISSUE SPECIFICITY

Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level). Detected in the islet of Langerhans.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.; Palmitoylated on Cys-243; which may be required for membrane targeting.; Phosphorylated on tyrosine residues. Phosphorylation increases in response to NRG1; this inhibits channel activity (By similarity). Phosphorylation at Ser-446 regulates channel activity by down-regulating expression at the cell membrane.

SUBCELLULAR LOCATION

Endoplasmic reticulum. Plasma membrane. Other locations.

FUNCTION

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons.