Metabotropic glutamate receptor 5 Recombinant Rabbit Monoclonal Antibody [ST51-00] (ET1609-36)

UNIPROT #

P41594

PROTEIN NAME

Metabotropic glutamate receptor 5

SYNONYMS

Glutamate receptor metabotropic 5 antibody;GPRC1E antibody;Grm5 antibody;GRM5_HUMAN antibody;Metabotropic glutamate receptor 5 antibody;Metabotropic glutamate receptor 5 variant F antibody;Metabotropic glutamate receptor 5 variant G antibody;Metabotropic glutamate receptor 5 variant H antibody;mGlu5 antibody;mGluR5 antibody;PPP1R86 antibody;Protein phosphatase 1 regulatory subunit 86 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 3 family.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The mGluR proteins (metabotropic Glutamate Receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-5, which can interact with SIAH-1, RyR-1, RyR-2, ITPR1, Shank 1, Shank 3 and GRASP, acts as a receptor for glutamate. The PPXXf motif of mGluR-5 binds to HOM1, HOM2 and HOM3.