NaV1.7 Mouse Monoclonal Antibody [1D6] EM1701-35

UNIPROT #

Q15858

PROTEIN NAME

NaV1.7

SYNONYMS

ETHA antibody;GEFSP7 antibody;hNE Na antibody;hNE-Na antibody;hNENa antibody;NE NA antibody;NENA antibody;Neuroendocrine sodium channel antibody;Peripheral sodium channel 1 antibody;PN1 antibody;Scn9a antibody;SCN9A_HUMAN antibody;Sodium channel protein type 9 subunit alpha antibody;Sodium channel protein type IX subunit alpha antibody;Sodium channel voltage gated type IX alpha antibody;Sodium channel voltage gated type IX alpha polypeptide antibody;Sodium channel voltage gated type IX alpha subunit antibody;Voltage gated sodium channel alpha subunit Nav1.7 antibody;Voltage gated sodium channel subunit alpha Nav1 antibody;Voltage-gated sodium channel subunit alpha Nav1.7 antibody

SEQUENCE SIMILARITIES

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily.

TISSUE SPECIFICITY

Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.; Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.

SUBCELLULAR LOCATION

Cell membrane, Cell projection.

FUNCTION

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.