Parvalbumin Recombinant Rabbit Monoclonal Antibody [JM100-08] (ET1703-15)

UNIPROT #

P20472

PROTEIN NAME

Parvalbumin

SYNONYMS

D22S749 antibody;MGC116759 antibody;Parvalbumin alpha antibody;PRVA_HUMAN antibody;PVALB antibody

SEQUENCE SIMILARITIES

Belongs to the parvalbumin family.

SUBCELLULAR LOCATION

Cytoplasm, nucleus.

FUNCTION

Parvalbumin (PV) is a calcium-binding protein with low molecular weight (typically 9-11 kDa). In humans, it is encoded by the PVALB gene. It is not a member of the albumin family; it is named for its size (parv-, from Latin parvus small) and its ability to coagulate. It has three EF hand motifs and is structurally related to calmodulin and troponin C. Parvalbumin is found in fast-contracting muscles, where its levels are highest, as well as in the brain and some endocrine tissues. Parvalbumin is a small, stable protein containing EF-hand type calcium binding sites. It is involved in calcium signaling. Calcium binding proteins like parvalbumin play a role in many physiological processes, namely cell-cycle regulation, second messenger production, muscle contraction, organization of microtubules and phototransduction. Therefore, calcium-binding proteins must distinguish calcium in the presence of high concentrations of other metal ions. The mechanism for the calcium selectivity has been extensively studied.