S100 alpha Recombinant Rabbit Monoclonal Antibody [JM51-31] (ET1703-72)

UNIPROT #

P23297

PROTEIN NAME

S100 alpha

SYNONYMS

Bpb antibody;NEF antibody;Protein S100-A1 antibody;S-100 protein alpha chain antibody;S-100 protein subunit alpha antibody;S100 alpha antibody;S100 Alpha Chain antibody;S100 antibody;S100 Beta Chain antibody;S100 Calcium Binding Protein A1 antibody;S100 Calcium Binding Protein B antibody;S100 Calcium Binding Protein Beta Neural antibody;S100 calcium-binding protein A1 antibody;S100 protein alpha polypeptide antibody;S100A antibody;s100a1 antibody;S10A1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the S-100 family.

TISSUE SPECIFICITY

Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100 α and β, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin α and parvalbumin β (also designated oncomodulin). The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. Research also indicates that the S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 α chain and S-100 β chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of either two α chains, two β chains or one α and one β chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 α and β are present in a variety of other tissues, and calbindin is present in intestine and kidney.